Early Pregnancy Serum Concentration of Secreted Frizzled-Related Protein 4, Secreted Frizzled-Related Protein 5, and Chemerin in Obese Women Who Develop Gestational Diabetes Mellitus

Background: The aim of this study was to evaluate whether secreted frizzled-related protein 4 (sFRP4), 5 (sFRP5), and chemerin serum concentrations in early pregnancy are associated with the development gestational diabetes mellitus (GDM) an obese cohort. In previous studies, increased sFRP4 chemerin, decreased sFRP5 were GDM normal overweight women. Methods: exploratory case control study, sFRP4, sFRP5, determined by ELISA 50 women who developed 100 uncomplicated pregnancies. Serum samples obtained between 15+0–18+6 weeks’ age based on a priori known associations GDM, body mass index (BMI) maternal selected for adjustment multivariate analyses. Results: cohort (median BMI 35.7 kg/m2, IQR 33.2–40.3 kg/m2), biochemical markers showed no association GDM: odds ratio (OR) 0.44 (95% confidence interval (CI) 0.01–23.18, p = 0.687), OR 0.55 CI 0.09–3.52, 0.528), 3.47 0.05–227.72, 0.560). Adjustment did not influence association. None significantly correlated insulin resistance (HOMA2-IR). Conclusion: No found or concentration pregnant absence may indicate that these proteins play lesser biological role pathophysiology